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Anti-TPO TPO, or Thyroid Peroxidase, is an enzyme that powers thyroid hormone production

The B12 is commonly used and prescribed medications are considered safe

Controls received vehicle only, BSO-only group received 125 mg/kg twice daily on days 1, 2 and 3 via intraperitoneal injection, L-PAM-only group received 10 mg/kg dose on days 2 and 3 given intravenously into the lateral tail vein, and the L-PAM+BSO group received both drugs as per above

Glucagon-like peptide-1 (GLP-1) is a weekly injectable medication that stimulates insulin release, slows gastric motility, reduces appetite, and stabilizes blood sugar

How the #incretin effect is impaired by #hyperglycemia in the brain and elsewhere through #glycolyticoverload